The Temporal Effect of Platelet-Rich Plasma on Pain and Physical Function in the Treatment of Knee Osteoarthritis: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Platelet rich plasma (PRP) injections to treat knee osteoarthritis are found to be superior to corticosteroids, ozone, hyaluronic acid, and saline placebo when comparing symptoms and function at 3, 6, and 12 months after injections. This study was published in 2017 and evaluated outcomes in 1,423 patients in 14 randomized control trials from a variety of clinics. This a systematic review and meta-analysis of existing studies and provides strong evidence to support use of PRP in knee osteoarthritis.

The Takeaway: This is a very powerful study that proves that regenerative medicine has significant benefits when compared to commonly used treatment approaches for knee osteoarthritis. It has also proven that PRP is better at improving symptoms and function while simultaneously lasting longer than the current standard of care methods.

Shen L, Et Al. The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. Journal of Orthopaedic Surgery and Research (2017) 12:16

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