Intra-Articular Platelet-Rich Plasma Injections for Knee Osteoarthritis: An Overview of Systematic Reviews and Risk of Bias Considerations.

Platelet rich plasma (PRP) publications were analyzed for quality and ultimately concluded that PRP is a safe and effective treatment for knee osteoarthritis without an increase of risk to the patient. This is a systematic review which strives to provide the best evidence within various medical databases after meeting the criteria of highest quality design and lowest chance of bias. 10 publications in total were selected to make this conclusion.

The Takeaway: Traditionally, high-dose steroids (commonly cortisone) are used to treat osteoarthritis but serial injections of such steroids in the knee puts patients at risk for worsening osteoarthritis, elevated blood sugar, increased blood pressure, a decline in bone mineral density, and decreased immune function. PRP is shown in this study to pose less risks to the patient when compared to other commonly used methods.

Reference:
Xing D, Et Al. Intra-articular platelet-rich plasma injections for knee osteoarthritis: An overview of systematic reviews and risk of bias considerations. Int J Rheum Dis. 2017 Nov;20(11):1612-1630.

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