Injecting Autologous Platelet-Rich Plasma Solely into the Knee Joint is Not Adequate in Treating Geriatric Patients with Moderate to Severe knee Osteoarthritis.

Moderate to severe knee osteoarthritis was found to be best treated when utilizing repeat ultrasound-guided platelet-rich plasma (PRP) injections to treat both inside the knee joint AND the soft tissue components around the knee joint. This study supports the idea that treating the joint comprehensively, meaning addressing all of the structures within that joint that stabilize the joint and contribute to its function. In this study, this comprehensive approach was compared to basic injections into the joint compartment, not including surrounding joint structures. Essentially, group 1 received a simple PRP injection into just the knee joint space (a technique used today by less sophisticated practitioners, and oftentimes a blind injection, meaning no image guidance used) and group 2 received PRP injections into multiple structures in the knee. Group 2 had a better outcome, and these outcomes were measured both on a cellular level based on the improved inflammatory protein analysis, and on a functional level as reported by the patients’ subsequent reduction of pain and improved mobility.

The Takeaway: IOW treats joint conditions using the same precise and comprehensive approach that this study reveals as superior when it comes to PRP technique for orthopedic applications. That means approaching the joint as a functional unit and injecting all components of the joint precisely under image guidance to support maximum healing of degenerative tissues that contribute to pain and dysfunction. Simple injections of PRP do not promote the max benefit overall to the patient, and technique does impact outcomes in a way that can be measured.

Chen CPC, Et Al. Injecting autologous platelet rich plasma solely into the knee joint is not adequate in treating geriatric patients with moderate to severe knee osteoarthritis. Exp Gerontol. 2019 May;119:1-6.

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