Comparison of the Clinical Effectiveness of Single Versus Multiple Injections of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Comparing single Platelet-Rich Plasma (PRP) injections to double or triple PRP injections into knees with osteoarthritis found no change in pain levels, BUT when evaluating for function, triple injections of PRP were found to improve function of the knee at 6 months. This study produced level 1 evidence after reviewing 3,816 studies which have been published from 1970 to 2019. After scrutiny of the articles, only 5 randomized control trials passed the criteria for low bias and adequate study design.

The Takeaway: This is a great example of how a series of treatments could give you continuously improved results. If you have found that one PRP treatment helped but didn’t get you where exactly you wanted, then additional treatments may get you there. It is actually a good sign when patients have a history of benefit from prior regenerative procedures because it tells the doctor that you are a good responder. We can then advance forward to treat remaining pain generators that may not have previously been addressed, or we may just need to modify the orthobiologics and/or concentrations for special circumstances. Thus far there is no evidence to suggest that multiple PRP treatments would cause any significant harm to the joints.

Reference:
Vilchez-Cavazos F, Et Al. Comparison of the Clinical Effectiveness of Single Versus Multiple Injections of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis. Orthop J Sports Med. 2019 Dec 16;7(12):2325967119887116.

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