Efficacy of Autologous Bone Marrow Concentrate for Knee Osteoarthritis With and Without Adipose Graft

This study found that the addition of an adipose graft to bone marrow concentrate (BMC) did not improve results of pain and function when compared to using BMC alone to treat knee osteoarthritis.

The Takeaway: Adipose (fat) can be used as a graft to buttress tissues for structural support. Adipose contains mesenchymal stem cells just like BMC, but they largely remain sequestered by the collagen, preventing the cells from acting on tissues. In large tears or other structural deficits, fat grafts have been used in combination with BMC in an effort to improve the treatment outcomes, but in this study, knee osteoarthritis specifically was not significantly improved.

Reference:
Centeno C, Et Al. Efficacy of autologous bone marrow concentrate for knee osteoarthritis with and without adipose graft. Biomed Res Int. 2014;2014:370621.

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