Anterior cruciate ligament tears treated with percutaneous injection of autologous bone
marrow nucleated cells: a case series

This study injected PRP into knees with mild to moderate osteoarthritis and compared the cartilage with MRI before and after treatment. They noted pain and functional improvements, but they also found that cartilage volume significantly improved!

The Takeaway: This is a very interesting article. I don’t usually expect PRP to grow more cartilage and I don’t set that expectation with my patients. I would expect bone marrow concentrate to be more effective in improving cartilage, but only under certain circumstances. To grow cartilage you need a foundation of cartilage to build upon, like that found in this study as grades 1, 2, and 3 but NOT grade 4, which is also known as “bone-on-bone” severe osteoarthritis. You don’t need to settle on just controlling your knee symptoms with medications and cortisone injections. It IS possible for your body to heal itself and usually the best results are had when treatment takes place before things get really bad.

Reference:
Raeissadat SA, Ghorbani E, Sanei Taheri M, Soleimani R, Rayegani SM, Babaee M, Payami S. MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Randomized Clinical Trial). J Pain Res. 2020 Jan 10;13:65-73.

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