Intra-Articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial

Knee injections with Platelet rich plasma (PRP) were found to be highly effective in treating mild to moderate osteoarthritis. In many instances, it was better than injections of hyaluronic acid and a saline placebo after one year. This study provided level one evidence of 53 patients, as a double blinded, randomized control trial that evaluated for pain, stiffness, physical function, and sports activities at baseline, and at 1, 2, 6, and 12 months after treatment.

The Takeaway: Regeneration of tissues works best when there is a foundation of integrity to start with, which is typically present in mild to moderate conditions. Structural integrity is usually poor in more severe conditions. Still, benefits of regenerative therapies such as PRP are seen in treating more severe conditions, but they may not last as long or the improvement may not be as profound. For the best outcomes, it’s always recommended to seek treatment early before your condition gets severe and further degeneration occurs.

Reference:
Lin K, Et Al. Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial. Arthroscopy. 2019 Jan;35(1):106-117.

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