Meta-Analysis Comparing Platelet-Rich Plasma vs Hyaluronic Acid Injection in Patients with Knee Osteoarthritis

Platelet-rich plasma (PRP) was compared to hyaluronic acid (HA) in 1,314 patients with knee osteoarthritis and found PRP to be more effective than HA in improving pain, function, stiffness, activities of daily living, and physical activity at 3, 6, and 12 months post-treatment.

The Takeaway: Hyaluronic acid is a good alternative to steroids and has relatively low side effects compared to cortisone, but it does not regenerate tissue and does not have the capacity to improve the strength of the knee components like PRP.

Reference:
Yanhong H, Et Al. Meta-analysis Comparing Platelet-Rich Plasma vs Hyaluronic Acid Injection in Patients with Knee Osteoarthritis. Pain Med. 2019 Jul 1;20(7):1418-1429

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