Understanding PRP Therapy Risks and Benefits

March 17, 20253 min read

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Platelet-Rich Plasma (PRP) therapy is a non-surgical treatment used to address orthopedic conditions that affect joints, tendons, and ligaments. It’s a regenerative procedure that uses a small sample of your own blood to support tissue repair and improve joint function.

At Interventional Orthopedics of Washington, we use PRP therapy to help patients stay active, delay or avoid orthopedic surgery, and improve movement without relying on long-term medications or invasive procedures.

What Is PRP Therapy?

PRP therapy starts with a simple blood draw. That sample is processed in a centrifuge to separate and concentrate the platelets which contain growth factors. These concentrated platelets are then injected into the joint or soft tissue area under image guidance. The goal is to support the body’s natural processes that maintain and repair joint structures.

This treatment can be part of a broader joint preservation strategy especially for patients dealing with early signs of joint degeneration or those who want to avoid surgery.

PRP Therapy: What to Know About Potential Risks

Like any procedure, PRP therapy comes with a few risks. Most are minimal and temporary, especially when performed by a trained provider in a clinical setting. Still, it’s important to understand what to expect. Possible risks include:

  • Mild pain or swelling at the injection site

  • Infection (rare but possible)

  • Nerve irritation

  • Reaction at the site of the injection

Can PRP Therapy Cause Blood Clots?

There have been rare reports of clotting concerns related to PRP therapy. Because PRP is made from your own blood, the body generally accepts it well, but clots after PRP are more likely to be caused by other medical issues.

That said, patients with a history of blood clots, clotting disorders, or cardiovascular issues should discuss those conditions with their provider. A full medical history review helps us understand individual risk factors and whether PRP therapy is appropriate.

Reducing Risk During PRP Treatment

At IOW, we take several steps to reduce risk and ensure every PRP procedure is performed safely and effectively:

  • Ultrasound or Fluoroscopic guidance is used to place the injection exactly where it’s needed

  • Sterile technique minimizes the risk of infection

  • Tailored PRP concentration is prepared based on your specific condition and tissue type

  • Pre- and post-procedure protocols are explained clearly, so you know what to expect

We also talk with you about medications you may be taking especially those that affect bleeding or clotting and we make sure your treatment plan is adjusted accordingly.

When PRP Therapy Makes Sense

PRP therapy may be a good option for people who are:

  • Dealing with chronic joint pain or recent soft tissue injuries

  • Looking to avoid surgery or reduce reliance on anti-inflammatory medications

  • Experiencing mild to moderate joint degeneration

  • Struggling with reduced function or mobility in a specific joint

It’s often used for knees, hips, shoulders, spine and elbows but we tailor it based on your specific diagnosis and goals.We commonly treat more than one joint at a time.

Is PRP Therapy Injections Safe?

Yes, PRP therapy is generally safe when performed by a qualified provider. While risks like infection or clotting exist, they are rare. Most patients experience mild soreness for a day or two, then return to normal activities shortly after.

At Interventional Orthopedics of Washington, we’ve helped many patients integrate PRP into their treatment plan as a way to delay surgery and stay active. Our team carefully evaluates every case to ensure PRP is the right fit.

Talk to Us About PRP Therapy

If you’re looking for a non-surgical option to improve joint function and reduce limitations, PRP therapy may be worth considering. Our team is here to help you weigh the risks and benefits, understand what’s involved, and decide whether it fits your care plan.

Contact us today to schedule a consultation and learn if PRP therapy is right for you.

Otono Silva, MD, is the founder of Interventional Orthopedics of Washington.

Otono Silva, MD

Otono Silva, MD, is the founder of Interventional Orthopedics of Washington.

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